Peptide library · Growth hormone axis
Sermorelin
GHRH 1-29 · Geref
Formerly FDA approved1997the year the FDA approved it (as Geref) for children with growth hormone deficiency
What it is
The first 29 amino acids of GHRH, the hormone that tells your pituitary to release growth hormone. It nudges your own GH rather than replacing it.
Why researchers are interested
- Was an FDA approved medicine for over a decade.
- Works upstream, so the body's own feedback loops stay in place.
- Widely used in clinics through compounding pharmacies.
Good to know
- The maker discontinued it in 2008 for business reasons, not safety. It's no longer an FDA approved product.
- Adult anti aging use hasn't been tested in large trials.
Evidence level: 3 of 5
Sources
Sermorelin (Geref) FDA approval 1997, discontinued 2008; endocrinology literature
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Educational content only. Not medical advice. Last reviewed 2026-10-17.