Peptide library · Recovery & repair
KPV
Lys-Pro-Val · alpha-MSH fragment
Research stage3amino acids. KPV is the tail end of alpha-MSH, a natural anti-inflammatory hormone
What it is
A tiny three amino acid peptide taken from the end of alpha-MSH, a hormone your body uses to dial down inflammation.
Why researchers are interested
- Reduced inflammation in mouse models of colitis, including when delivered orally in nanoparticles.
- Studied for skin and gut inflammation in the lab.
- An FDA advisory panel recommended it for pharmacy compounding in July 2026.
Good to know
- Not FDA approved. FDA hasn't acted on the panel's recommendation yet.
- Human data is very limited.
Evidence level: 2 of 5
Sources
Laroui et al., Gastroenterology 2010; RAPS, FDA advisory committee, July 2026
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Educational content only. Not medical advice. Last reviewed 2026-10-17.